Myeloid PD1 in the frame

L Bird - Nature Reviews Immunology, 2020 - nature.com
L Bird
Nature Reviews Immunology, 2020nature.com
T cells expressing programmed cell death 1 (PD1) have been considered the main targets of
immune checkpoint blockade therapy. But a new study shows that targeting PD1 on myeloid
cells reprogrammes tumour-induced myelopoiesis to favour maturation of effector myeloid
cells that promote antitumour immunity.
T cells expressing programmed cell death 1 (PD1) have been considered the main targets of immune checkpoint blockade therapy. But a new study shows that targeting PD1 on myeloid cells reprogrammes tumour-induced myelopoiesis to favour maturation of effector myeloid cells that promote antitumour immunity.
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