Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions
JC Woloszynek, Y Hu, CTN Pham - Journal of Biological Chemistry, 2012 - ASBMB
Neutrophil serine proteases play an important role in inflammation by modulating neutrophil
effector functions. We have previously shown that neutrophils deficient in the serine
proteases cathepsin G and neutrophil elastase (CG/NE neutrophils) exhibit severe defects in
chemokine CXCL2 release and reactive oxygen species (ROS) production when activated
on immobilized immune complex. Exogenously added active CG rescues these defects, but
the mechanism remains undefined. Using a protease-based proteomic approach, we found …
effector functions. We have previously shown that neutrophils deficient in the serine
proteases cathepsin G and neutrophil elastase (CG/NE neutrophils) exhibit severe defects in
chemokine CXCL2 release and reactive oxygen species (ROS) production when activated
on immobilized immune complex. Exogenously added active CG rescues these defects, but
the mechanism remains undefined. Using a protease-based proteomic approach, we found …
