Cardiac Allograft Vasculopathy (CAV) is a leading contributor to late transplant rejection.
Although implicated, the mechanisms by which bone marrow-derived cells promote CAV
remain unclear. Emerging evidence implicates the cell surface receptor tyrosine kinase AXL
to be elevated in rejecting human allografts. AXL protein is found on multiple cell types,
including bone marrow-derived myeloid cells. The causal role of AXL from this compartment
and during transplant is largely unknown. This is important because AXL is a key regulator …