[HTML][HTML] The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration
Phosphatidylinositol-specific phospholipase Cγ2 (PLCγ2) is a critical signaling molecule
activated downstream from a variety of cell surface receptors that contain an intracellular
immunoreceptor tyrosine-based activation motif. These receptors recruit kinases such as
Syk, BTK, and BLNK to phosphorylate and activate PLCγ2, which then generates 1D-myo-
inositol 1, 4, 5-trisphosphate and diacylglycerol. These well-known second messengers are
required for diverse membrane functionality including cellular proliferation, endocytosis, and …
activated downstream from a variety of cell surface receptors that contain an intracellular
immunoreceptor tyrosine-based activation motif. These receptors recruit kinases such as
Syk, BTK, and BLNK to phosphorylate and activate PLCγ2, which then generates 1D-myo-
inositol 1, 4, 5-trisphosphate and diacylglycerol. These well-known second messengers are
required for diverse membrane functionality including cellular proliferation, endocytosis, and …