[HTML][HTML] Solution structure of human growth arrest and DNA damage 45α (Gadd45α) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A …
R Sánchez, D Pantoja-Uceda, J Prieto, T Diercks… - Journal of biological …, 2010 - ASBMB
Gadd45α is a nuclear protein encoded by a DNA damage-inducible gene. Through its
interactions with other proteins, Gadd45α participates in the regulation of DNA repair, cell
cycle, cell proliferation, and apoptosis. The NMR structure of human Gadd45α has been
determined and shows an α/β fold with two long disordered and flexible regions at the N
terminus and one of the loops. Human Gadd45α is predominantly monomeric in solution but
exists in equilibrium with dimers and other oligomers whose population increases with …
interactions with other proteins, Gadd45α participates in the regulation of DNA repair, cell
cycle, cell proliferation, and apoptosis. The NMR structure of human Gadd45α has been
determined and shows an α/β fold with two long disordered and flexible regions at the N
terminus and one of the loops. Human Gadd45α is predominantly monomeric in solution but
exists in equilibrium with dimers and other oligomers whose population increases with …
