Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells
S Malik, RG Roeder - Trends in biochemical sciences, 2000 - cell.com
S Malik, RG Roeder
Trends in biochemical sciences, 2000•cell.comA novel multiprotein complex has recently been identified as a coactivator for transcriptional
control of protein-encoding genes by RNA polymerase II in higher eukaryotic cells. This
complex is evolutionarily related to the Mediator complex from yeast and, on the basis of its
structural and functional characteristics, promises to be a key target of diverse regulatory
circuits.
control of protein-encoding genes by RNA polymerase II in higher eukaryotic cells. This
complex is evolutionarily related to the Mediator complex from yeast and, on the basis of its
structural and functional characteristics, promises to be a key target of diverse regulatory
circuits.
Abstract
A novel multiprotein complex has recently been identified as a coactivator for transcriptional control of protein-encoding genes by RNA polymerase II in higher eukaryotic cells. This complex is evolutionarily related to the Mediator complex from yeast and, on the basis of its structural and functional characteristics, promises to be a key target of diverse regulatory circuits.
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